The original origami

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The paradox of protein folding

A paper crane appears impressively intricate, especially to a novice origami maker struggling with the first creases. But fumbling hands and crumpled paper belie a different type of folding expertise. Imperceptibly, legions of molecules inside the origami maker’s body constantly confront a much more complex folding task. These molecules, called proteins, reliably fold into one out of an enormous number of possible structures in a fraction of the time it takes to make a paper crane. With no hands to guide it, each protein molecule must traverse the pathway to its correct shape with superhuman speed and precision. And while poor origami technique results in wasted paper at worst, the consequence for failed protein folding can be death.

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